They work well.
Here's a dyno of a 16g gas setup from 2007:
Blue line is the Cyclone, red is a 1G Stock manifold.
The record for max power on a Cyclone was 621 HP on a DJ using a laggy GT-35:
I suspect like scheides said, it would be a restriction on high-flow setups, but I have absolute data from back-to-back runs with the same setup.