Tuning for higher base fuel pressure

[cman3000]

I am currently running PTE 880s with e85 at 18psi, and I am getting high IDCs. Is it acceptable to raise fuel pressure to take some of the work off the injectors? I am running a 255 pump, and I was only flowing around 170 lph while my injectors were maxing out.

From my understanding, If I were to run, say, 50 psi, I would have to decrease global by about 15% (1-sqrt(50/37.5)=-.15) Are there any other factors I would have to worry about, such as changing deadtime or MAFcomp?